What Is The Role of Raman Spectrometer in Life Science Research?
In life science, Raman spectroscopy can identify and distinguish the sample, by the precision of a single cell level. In the near future, the combination of Raman spectroscopy and microscope technology will bring great benefits to life science research.
From the trend of Raman spectroscopy development, Surface-enhanced Raman Spectroscopy (SERS) had been widely used in the life science research, in which the SERS is used to enhance the signals in the specific analysis. Moreover, the instrument combined with Atomic Force Microscopy (AFM) and Tip-enhanced Raman Spectroscopy (TERS) appears in the nanoscale research and analysis.
From the technical point of view, Raman spectroscopy has the following booming technologies:
Laser Trapping
Under the highly focused laser beam, by using the balance of optical gradient forces and the transfer of photon momentum, one can capture microscopic dielectric particles. This capture method, is able to improve the stability of the particles positioning and further increase the accuracy of Raman spectroscopy. Moreover, when this method is applied in aqueous stream, in addition to keeping the native state, it can be cooled by the flowing liquid.
Cell Sorting
There are already practical applications, which are using Raman microscopy with microfluidic chip in the research. The well-focused laser via the objective lens of microscope with optical tweezers, it is able to shorten the time of acquisition of Raman signal. By using Raman spectroscopy, accelerates the speed of cells capturing, analyzing, and sorting. Today, this technology, has been able to sort out a single cell from the complicated samples, such as biofilm, soil, sludge and tissues.
Biology Probing
The disease is not easy to be detected in the early stage, because its biomarker characteristics is very weak. By Surface-enhanced Raman Spectroscopy (SERS), we’re able to amplify the Raman vibration signal, and then highlight the specific biological markers. In addition, Tip-enhanced Raman Spectroscopy (TERS) combined with AFM, is also booming in life science. This instrument has the sensitivity of SERS, as well as the ultrahigh spectral resolution, from the AFM.
The common applications of the modern Raman spectroscopy in life sciences includes:
- Pharmacology
- Clinical research
- Cellular
- Proteomics
- Immunology
- Genomics
- Cosmetology
- Biomaterial
- Environmental
- Biosecurity
ACTTR Technology brought to you the high quality Raman Spectrometer. ACTTR will be your best partner in the life science research.